New Players in Macrophage Polarization
The field of Immunometabolism is the new frontier for Immunology as it integrates the historically distinct disciplines of Metabolism and Immunology. The growing interest in Immunometabolism is fueled by the global obesity epidemic and the strong association between inflammation and metabolic disease. Obesity-induced inflammation is a risk factor for several chronic pathologies and diseases. Investigating how the metabolic status of the immune system is altered under obesigenic conditions will provide insight into new mechanisms and therapeutic targets underlying immunometabolic regulation and homeostasis. Macrophage polarization is regulated by several factors in obese states. Our focus is to determine how macrophage polarization is regulated in obese states.