PROF. PEDRO M. M. MORAES VIEIRA
The field of Immunometabolism is the new frontier for Immunology as it integrates the historically distinct disciplines of Metabolism and Immunology. The growing interest in Immunometabolism is fueled by the global obesity epidemic and the strong association between inflammation and metabolic disease. Obesity-induced inflammation is a risk factor for several chronic pathologies and diseases. Investigating how the metabolic status of the immune system is altered under obesigenic conditions will provide insight into new mechanisms and therapeutic targets underlying immunometabolic regulation and homeostasis.
Brazilian Congress of Immunology
October 2017
INFLAMMA 2017
May 2017
UPCOMING EVENTS
Integrating Metabolism and Immunity
29.05.2017
MY LATEST RESEARCH
FAHFAs are a novel class of endogenous lipids with anti-inflammatory and anti-diabetic properties. Our main focus is to determine the immunoregulatory mechanisms by which FAHFAs exert their immunoregulatory role.
A major cause of type 2 diabetes is impaired insulin action in adipose tissue (AT), skeletal muscle and liver and even without diabetes. Adipokines are modulated by obese states and several adipokines have an direct role with several components of the metabolic syndrome in humans. Obesity is a state of chronic, low-grade inflammation, and macrophages are though to play an important role in maintaining this state. Emerging evidence suggests a possible role for pro-inflammatory pathways in adipokine-regulated insulin resistance. Leptin and RBP4 expression in AT and serum levels strongly correlate with subclinical inflammation, including adipose tissue expression of pro-inflammatory cytokines.